Alternate-day fasting. Go back and forth between feasting days and fasting days. Eat like a king or queen one day, then eat nothing the next. This will probably be the most challenging fasting option for most people. If you try it, make sure you’re eating a ton on your feast days, otherwise you’ll fall into a major calorie deficit and you’ll likely feel miserable.
Those studies above, in working with small sample sizes, and different types of fasting than recommended here, would lead me to believe that fasting affects men and women differently, and that many of the weight loss benefits associated with intermittent fasting (that affect insulin and glucose responses) work positively for men and negatively for women.
Before the Nobel Prize was awarded to Yoshinori Ohsumi, other researchers were making groundbreaking discoveries about autophagy. In 2009, an article was published in Cell Metabolism entitled Autophagy Is Required to Maintain Muscle Mass. In this article, researchers described how deactivating an important autophagy gene resulted in a profound loss in muscle mass and strength.
Diet soda doesn't contain any sugar, calories or carbohydrates, so it may seem like it's OK for fasting, but it's not that simple. Diet soda and other diet drinks are filled with artificial sweeteners, which can drastically increase sugar cravings, making fasting more challenging. Artificial sweeteners can also increase insulin resistance, which makes it harder to lose weight and increase your risk of developing diabetes.
Since all of your hormones are so deeply interconnected, when one hormone is thrown off balance, the rest are also negatively impacted. It’s like a domino effect. As the “messengers” that regulate nearly every function in your body — from energy production to digestion, metabolism, and blood pressure — you don’t want to disrupt their natural rhythm.
I’ll share some of my experiences, now doing heavy strength training for 3 years in a fasted state: For my first “fasted” workout or two after starting an IF protocol, it was very weird to not eat before training. However, after a few sessions, I learned that my body could certainly function (and even thrive) during my training sessions despite not eating a pre-workout meal.

Initial human studies that compared fasting every other day to eating less every day showed that both worked about equally for weight loss, though people struggled with the fasting days. So I had written off IF as no better or worse than simply eating less, only far more uncomfortable. My advice was to just stick with the sensible, plant-based, Mediterranean-style diet.
Cons: Even though it’s nice to eat a few snacks rather than go without any food for 20-plus hours, the guidelines for what you need to eat (and when) can be hard to follow long-term. The strict schedule and meal plan may also interfere with social gatherings. Additionally, eating one main meal at night — while following strict guidelines of what to eat, and in what order — can be tough. It’s especially hard for those who prefer not to eat large meals late in the day.
Two ground-breaking studies have recently been published on the effects of intermittent fasting on males. One group of researchers studied the effects that 16 hours of intermittent fasting had on males that lift weights. They found that muscle mass stayed the same, fat mass decreased significantly, and the males who fasted for 16 hours a day burned more fat for fuel compared to the control group that only fasted for 12 hours.
With this information in hand, you should know exactly how to schedule meals when starting an intermittent fasting plan. And while it might seem complicated at first, once you get into the habit of fasting, it will feel like second nature and fit pretty seamlessly into your days. Just remember to always start slow and gradually work up to more advanced plans.
If you're looking to lose weight, this isn't a problem. And even if you're happy with your weight, this won't prove to be too much of an issue if you follow the daily fasting or weekly fasting schedules. However, if you're fasting for 24 hours per day on multiple days per week, then it's going to be very difficult to eat enough of your feast days to make up for that.

Cons: Even though there is flexibility in when you eat, Leangains has pretty specific guidelines for what to eat, especially in relation to when you’re working out. The strict nutrition plan and scheduling meals perfectly around workouts can make the program a bit tougher to adhere to. (You can learn more about the specifics — as well as when to time these meals — directly from Leangains here and here.)
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Islam is the only major religion that engages in a fasting practice reflective of intermittent fasting in terms of both food consumption and diet consistency.[12] The duration of the Ramadan fast is between 28 and 30 days, depending on the year, and consists of not eating or drinking from sunrise until sunset.[12] During the holiday, Muslims eat twice per day: once in the morning before dawn and once in the evening after dusk.[12] A meta-analysis on the health of Muslims during Ramadan shows significant weight loss during the fasting period of up to 1.51 kilograms (3.3 lb), but this weight was regained within about two weeks of Ramadan ending.[13] The analysis concluded that "Ramadan provides an opportunity to lose weight, but structured and consistent lifestyle modifications are necessary to achieve lasting weight loss."[13] Negative effects of Ramadan fasting include increased risk of hypoglycemia in diabetics as well as inadequate levels of certain nutrients.[12]


Hello Maria, I can honestly say I look forward to my morning black coffee now, just as much as I enjoy a cup with a little cream, once my eating window opens late afternoon. My easiest “go-to” tip is adding just the smallest pinch of pink Himalayan salt to my coffee. It really works to smooth out the black coffee bitterness! Good luck with your IF journey, Maria!
Well, most notably, it’s a great way to get lean without going on a crazy diet or cutting your calories down to nothing. In fact, most of the time you'll try to keep your calories the same when you start intermittent fasting. (Most people eat bigger meals during a shorter time frame.) Additionally, intermittent fasting is a good way to keep muscle mass on while getting lean.

In practice, however, I would be concerned with eating enough. Based on my experience, teaching yourself to consistently eat more is one of the harder parts of intermittent fasting. You might be able to feast for a meal, but learning to do so every day of the week takes a little bit of planning, a lot of cooking, and consistent eating. The end result is that most people who try intermittent fasting end up losing some weight because the size of their meals remains similar even though a few meals are being cut out each week.
It doesn't matter when you start your 8–hour eating period. You can start at 8am and stop at 4pm. Or you start at 2pm and stop at 10pm. Do whatever works for you. I tend to find that eating around 1pm and 8pm works well because those times allow me to eat lunch and dinner with friends and family. Breakfast is typically a meal that I eat on my own, so skipping it isn't a big deal.
This is excellent, thank you! One thing I would love to see added to this research is the keto effect of just water over those 120 minutes, and THEN the keto effect of adding a tad bit of protein, such as collagen powder (I use the green tub great lakes powder; it dissolves great in coffee). I feel like that might put your test even more into an annals of science, and for us folks who don’t have the finger prick blood testers, it would be fun to know. Also, sugar free sweeteners like splenda (!!) or stevia–do they have any effect? Anyway–great read, exactly what I was looking for when I googled my question.
A 2018 review of intermittent fasting in obese people showed that reducing calorie intake one to six days per week over at least 12 weeks was effective for reducing body weight on an average of 7 kilograms (15 lb); the results were not different from a simple calorie restricted diet, and the clinical trials reviewed were run mostly on middle-aged women from the US and the UK, limiting interpretation of the results.[25] Intermittent fasting has not been studied in children, the elderly, or underweight people, and could be harmful in these populations.[25][26]
Before you start your IF plan, it's important to talk with a professional to make sure it's right for you. Women should be especially cautious as there are some mixed opinions on whether or not certain fasting protocols are healthy for female hormone balance. In addition, if you have adrenal fatigue or gut health issues you'll want to proceed with caution. If you have a history of disordered eating, you'll probably want to avoid fasting altogether..
After determining your preferred protocol of intermittent fasting, you should start planning out your diet for the days that you do eat. On a standard keto diet, 75 percent of total calories should come from fat, 20 percent should be from protein and 5 percent should come from carbs. When getting started, however, you can start with a modified keto diet instead, which is often considered more flexible and easy-to-follow. With this diet plan, about 40–60 percent of calories should come from healthy keto fats with 20–30 percent from protein foods and 15–25 percent from carbohydrates.
Eat one large meal per day, cutting out all other meals and snacks. For those who aren’t interested in checking clocks and calendars, this is probably the easiest option. This is also a good choice for busy individuals who have a lot going on during the day. Just skip breakfast and lunch and have a large dinner that will carry you over through until bedtime.
In Prime Women’s recently launched PLATE weight management program, Dr. Kathryn Waldrep recommends eating within a nine hour window and choosing that time frame based on your body’s circadian rhythms. Early risers might eat between 9:00 am and 6:00 pm. Night owls would eat their first meal at noon and finish their last meal at 9:00 in the evening. As more and more research has been done around IF and circadian rhythms, there seems to be more and more evidence on the soundness of this approach to eating for weight management.
So does that mean you should abstain from your caffeine fix when fasting? According to Dr. Josh Axe, D.N.M., C.N.S., D.C., founder of DrAxe.com, bestselling author of Eat Dirt, and cofounder of Ancient Nutrition, tea and coffee are fine to consume as long as you don't add any milk or sweeteners. He explains on his blog, "If you're on a time-restricted fast and you're in no-eating hours, it's best to stick to no- or low-calorie drinks like water, coffee, (with no milk) and tea. If you're on an alternate day diet or something similar, even during low calorie hours, you can technically drink whatever you'd like — but remember, this will count against your calories." Dr. Palanisamy also agrees that during fasting, the "appetite-suppressing effects of coffee are probably beneficial."
Some people believe that IF has worked for them simply because the limited eating window naturally helps them reduce the amount of calories they consume. For instance, instead of eating three meals and two snacks, they might find that they only have time for two meals and one snack. They become more mindful about the kinds of food they consume and tend to stay way from processed carbs, unhealthy fat, and empty calories.
Cons: Even though there is flexibility in when you eat, Leangains has pretty specific guidelines for what to eat, especially in relation to when you’re working out. The strict nutrition plan and scheduling meals perfectly around workouts can make the program a bit tougher to adhere to. (You can learn more about the specifics — as well as when to time these meals — directly from Leangains here and here.)

Other studies have found that fasting was as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of chemotherapeutic drugs against melanoma, glioma, and breast cancer cells. Although this research may not apply to your life, it does suggest that intermittent fasting can help support your body in times of toxic stress.

Also, be aware that when you exercise, your body directly burns away glycogen (a form of glucose stored in the muscles). Fasting depletes these stores, which can mean less available energy for the muscles to use when they need it. This can lead to extreme fatigue and decreased performance. The best fasting tips for athletes are to precede each workout with a low-calorie protein shake designed to deliver creatine, BCAAs, beta-alanine, and other amino acids directly to the muscles as they work them, and then to follow each workout with a whey-protein supplement to replenish depleted nutrient stores in order to speed up the recovery process. These workout supplements won’t add much to your overall calorie count, and will help ensure that your intermittent fasting schedule and your workout regimen aren’t getting in each other’s way.
So very interesting, I was captivated reading your results—thank you! I would also love to see added to this research the keto effect of just water over those 120 minutes, and then the keto effect of adding collagen powder to your coffee. So appreciative of all that wincing-sticking-your-fingers that you both endured to help give us clarity in what goes on with our ketones and glucose when drinking our coffees with different add-ins. Great read!

In fact, the authors of this book said that they had patients who only changed their eating habits with this twelve- to sixteen-hour “fruit” fast each day. They did not follow the diet’s other rules or count calories, and they still lost weight and got healthier. This strategy might have simply worked because the dieters replaced junk food with whole foods. In any case, people found this dietary change effective and easy to make. Traditionalists won’t call this fasting; however, it’s important to know that you may have options if you absolutely can’t abstain from food for several hours at a time.

I’ve read several places that adding gelatin or collagen to coffee breaks the fast, but I don’t understand why since there are no carbs, only protein, and fewer than 50 calories per tablespoon. Have you tested this? It would be great to be able to add protein to my morning coffee so I would love to know. Would also love to know if one tablespoon of coconut cream affects ketones and glucose.


Yes — you read that correctly — 24 hours of intermittent fasting without any resistance training and these subjects were able to preserve more muscle mass than the subjects that ate fewer calories every day without fasting at all. This finding contradicts our common sense, but when we dig deeper into autophagy we can find the mechanism behind this result.
Initial human studies that compared fasting every other day to eating less every day showed that both worked about equally for weight loss, though people struggled with the fasting days. So I had written off IF as no better or worse than simply eating less, only far more uncomfortable. My advice was to just stick with the sensible, plant-based, Mediterranean-style diet.
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