Those studies above, in working with small sample sizes, and different types of fasting than recommended here, would lead me to believe that fasting affects men and women differently, and that many of the weight loss benefits associated with intermittent fasting (that affect insulin and glucose responses) work positively for men and negatively for women.
Because we don't enter the fasted state until 12 hours after our last meal, it's rare that our bodies are in this fat burning state. This is one of the reasons why many people who start intermittent fasting will lose fat without changing what they eat, how much they eat, or how often they exercise. Fasting puts your body in a fat burning state that you rarely make it to during a normal eating schedule.
Whichever option you choose, there's enough evidence to show that intermittent fasting has many health benefits. Dr. Palanisamy sums it up best by saying, "The final caveat is that some fasting is better than none. So if having a regular or even bulletproof coffee is the only way that you can stick with the practice of intermittent fasting, then it's probably worth it."
How It Works: Fast for 14 (women) to 16 (men) hours each day, and then “feed” for the remaining eight to 10 hours. During the fasting period, you consume no calories. However, black coffee, calorie-free sweeteners, diet soda and sugar-free gum are permitted. (A splash of milk in your coffee won’t hurt, either.) Most practitioners will find it easiest to fast through the night and into the morning. They usually break the fast roughly six hours after waking up. This schedule is adaptable to any person’s lifestyle, but maintaining a consistent feeding window time is important. Otherwise, hormones in the body can get thrown out of whack and make sticking to the program harder, Berkhan says.
There’s a ton of incredibly promising intermittent fasting (IF) research done on fat rats. They lose weight, their blood pressure, cholesterol, and blood sugars improve… but they’re rats. Studies in humans, almost across the board, have shown that IF is safe and incredibly effective, but really no more effective than any other diet. In addition, many people find it difficult to fast.
Because of the massive amount of sugar that Americans eat on average, most people have become dependent on glucose, instead of fatty acids, for energy. Every supermarket, grocery store and coffee shop sells an abundance of sugary foods and drinks. When you eat a lot of sugar, and that sugar isn't utilized for energy, your body breaks it down and eventually stores it as body fat.
The biggest concern most people have is that Intermittent Fasting will lead to lower energy, focus, and the “holy crap I am hungry” feeling during the fasting period and ruin them. People are concerned that they will spend all morning being miserable because they haven’t consumed any food, and thus will be miserable at work and ineffective at whatever task it is they are working on.