Before the Nobel Prize was awarded to Yoshinori Ohsumi, other researchers were making groundbreaking discoveries about autophagy. In 2009, an article was published in Cell Metabolism entitled Autophagy Is Required to Maintain Muscle Mass. In this article, researchers described how deactivating an important autophagy gene resulted in a profound loss in muscle mass and strength.

Conversely, a 2013 study completed by researchers at Washington University School of Medicine, presented the exact opposite, showing increased reactions in receptors on the tongue, when participants were given artificial sweeteners. Their study concluded that if the receptors are capable of detecting sweetness, even though calories aren’t present, a hormonal response (insulin release) is likely.
As a lifestyle-leaning research doctor, I needed to understand the science. The Obesity Code seemed the most evidence-based summary resource, and I loved it. Fung successfully combines plenty of research, his clinical experience, and sensible nutrition advice, and also addresses the socioeconomic forces conspiring to make us fat. He is very clear that we should eat more fruits and veggies, fiber, healthy protein, and fats, and avoid sugar, refined grains, processed foods, and for God’s sake, stop snacking. Check, check, check, I agree. The only part that was still questionable in my mind was the intermittent fasting part.
Weight-loss resistance can often be due to an underlying hormone imbalance. Leptin resistance occurs when your brain stops recognizing leptin's signals to use your body’s fat stores for energy. This causes your body to continually store fat instead of using it. Intermittent fasting has been shown to improve chronic inflammation that can dull the brain’s leptin receptor sites.

As a lifestyle-leaning research doctor, I needed to understand the science. The Obesity Code seemed the most evidence-based summary resource, and I loved it. Fung successfully combines plenty of research, his clinical experience, and sensible nutrition advice, and also addresses the socioeconomic forces conspiring to make us fat. He is very clear that we should eat more fruits and veggies, fiber, healthy protein, and fats, and avoid sugar, refined grains, processed foods, and for God’s sake, stop snacking. Check, check, check, I agree. The only part that was still questionable in my mind was the intermittent fasting part.


You drink sugary beverages, digest them quickly and store the leftovers as body fat. After the initial spike in blood sugar, you experience a dramatic drop, which prompts you to eat more, and what happens? You store more fat. Because of this, it's best to avoid sugary drinks, like soda, lemonade, fruit juices, sweetened iced tea and even some kombucha, completely, whether you're fasting or not.
Whichever option you choose, there's enough evidence to show that intermittent fasting has many health benefits. Dr. Palanisamy sums it up best by saying, "The final caveat is that some fasting is better than none. So if having a regular or even bulletproof coffee is the only way that you can stick with the practice of intermittent fasting, then it's probably worth it."

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Crescendo fasting only requires you to fast a few days a week instead of every day. My experience is that women get a lot more benefit from doing it this way without accidentally throwing their hormones into frenzy. This is a more gentle approach that helps the body more easily adapt to fasting. And if women do it right, it can be an amazing way to shave off body fat, improve inflammatory markers and gain energy. (7)
What and when you eat during the feeding window also depends on when you work out. On days you exercise, carbs are more important than fat. On rest days, fat intake should be higher. Protein consumption should be fairly high every day, though it will vary based on goals, gender, age, body fat and activity levels. Regardless of your specific program, whole, unprocessed foods should make up the majority of your calorie intake. However, when there isn’t time for a meal, a protein shake or meal replacement bar is acceptable (in moderation).
The four-hour eating window — which Hofmekler refers to as the “overeating” phase — is at night in order to maximize the Parasympathetic Nervous System’s ability to help the body recuperate, promoting calm, relaxation and digestion, while also allowing the body to use the nutrients consumed for repair and growth. Eating at night may also help the body produce hormones and burn fat during the day, according to Hofmekler. During these four hours, the order in which you eat specific food groups matters, too. Hofmelker says to start with veggies, protein and fat. After finishing those groups, only if you are still hungry should you tack on some carbohydrates.
Alternate-day fasting. Go back and forth between feasting days and fasting days. Eat like a king or queen one day, then eat nothing the next. This will probably be the most challenging fasting option for most people. If you try it, make sure you’re eating a ton on your feast days, otherwise you’ll fall into a major calorie deficit and you’ll likely feel miserable.

Both the keto diet and intermittent fasting trigger something referred to as autophagy. The latter is simply the technical term for a natural bodily function called “self-eating.” Although at first this may sound a bit frightening, autophagy is merely your body’s normal detoxification process, during which it eliminates contaminants and replaces them with newly formed, healthy cells.
Because we don't enter the fasted state until 12 hours after our last meal, it's rare that our bodies are in this fat burning state. This is one of the reasons why many people who start intermittent fasting will lose fat without changing what they eat, how much they eat, or how often they exercise. Fasting puts your body in a fat burning state that you rarely make it to during a normal eating schedule.

Intermittent fasting isn't a regimen built around limiting calories (although it's likely that your calorie intake will be restricted naturally since you're going a period of time without eating), but it can promote weight loss in a big way. Fasting gives your metabolism an overhaul. It works on the same principles as a ketogenic diet. By restricting food (and carbohydrates), you'll switch your body from burning glucose for energy to burning stored body fat.


Coffee is an amazing drink. Zero calories, energizing, and taste good. No freaking wonder, it’s popular in the world. Some restraint needs to be instilled and it must not drink in excess though. That being said, the servings suggested is 4 or fewer cups of morning mud per day. Another great side effect of coffee is its ability to hold off hunger. Thus helping you achieve the desired Kinobody 16 hour intermittent fast.

Based on this, researchers from the University of Alabama conducted a study with a small group of obese men with prediabetes. They compared a form of intermittent fasting called “early time-restricted feeding,” where all meals were fit into an early eight-hour period of the day (7 am to 3 pm), or spread out over 12 hours (between 7 am and 7 pm). Both groups maintained their weight (did not gain or lose) but after five weeks, the eight-hours group had dramatically lower insulin levels and significantly improved insulin sensitivity, as well as significantly lower blood pressure. The best part? The eight-hours group also had significantly decreased appetite. They weren’t starving.
So if both musicians and adamantium-clawed superheroes do Intermittent Fasting, it can probably work for you too, if you can make it work for your particular lifestyle and situation! If you’ve tried implementing something like this in the past and not had success, or you’re just looking for guidance from a coach to help you implement it into your lifestyle, I hear ya!
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