Those studies above, in working with small sample sizes, and different types of fasting than recommended here, would lead me to believe that fasting affects men and women differently, and that many of the weight loss benefits associated with intermittent fasting (that affect insulin and glucose responses) work positively for men and negatively for women.
Fasting helps you build a better brain, too. Intermittent fasting increases a protein in your brain called BDNF that researchers have nicknamed “Miracle-Gro for your brain.”[7] BDNF improves learning and memory and can help you forge stronger neural pathways, making your brain run faster and more efficiently, which is especially important as you age.

This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
One monk, for example, set out to do a 40 day fast with medical supervision while maintaining his daily activities in the monastery. After 36 days, the medical professionals had to step in due to “profound weakness” and low blood pressure when standing. Although the monk fasted for 15 days longer than Ghandi, the medical professionals were able to stop the fast in time so that he could recover.

Expect funny looks if you spend a lot of mornings with breakfast eaters.  A few weeks back I had a number of friends staying with me, and they were all completely dumbfounded when I told them I didn’t eat breakfast anymore. I tried to explain it to them but received a bunch of blank stares. Breakfast has become so enGRAINed (zing!) in our culture that NOT eating it sounds crazy.  You will get weird looks from those around you…embrace it. I still go to brunch or sit with friends, I just drink black coffee and enjoy conversation.


Both the keto diet and intermittent fasting trigger something referred to as autophagy. The latter is simply the technical term for a natural bodily function called “self-eating.” Although at first this may sound a bit frightening, autophagy is merely your body’s normal detoxification process, during which it eliminates contaminants and replaces them with newly formed, healthy cells.
^ Jump up to: a b c Harris, L; Hamilton, S; Azevedo, LB; Olajide, J; De Brún, C; Waller, G; Whittaker, V; Sharp, T; Lean, M; Hankey, C; Ells, L (February 2018). "Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis". JBI Database of Systematic Reviews and Implementation Reports. 16 (2): 507–547. doi:10.11124/JBISRIR-2016-003248. PMID 29419624.
Cons: Going 24 hours without any calories may be too difficult for some — especially at first. Many people struggle with going extended periods of time with no food, citing annoying symptoms including headaches, fatigue, or feeling cranky or anxious (though these side effects can dimish over time). The long fasting period can also make it more tempting to binge after a fast. This can be easily fixed… but it takes a lot of self-control, which some people lack.
Also, be aware that when you exercise, your body directly burns away glycogen (a form of glucose stored in the muscles). Fasting depletes these stores, which can mean less available energy for the muscles to use when they need it. This can lead to extreme fatigue and decreased performance. The best fasting tips for athletes are to precede each workout with a low-calorie protein shake designed to deliver creatine, BCAAs, beta-alanine, and other amino acids directly to the muscles as they work them, and then to follow each workout with a whey-protein supplement to replenish depleted nutrient stores in order to speed up the recovery process. These workout supplements won’t add much to your overall calorie count, and will help ensure that your intermittent fasting schedule and your workout regimen aren’t getting in each other’s way.
The benefits of intermittent fasting translate to untrained overweight and obese individuals as well. One study published in Obesity Reviews found that eating fewer calories is effective for fat loss, but it does come with some muscle loss. However, if the subjects fasted for 24 hours and ate as much as they wanted on the next day for a period of 12 weeks, they lost significantly less muscle mass.

Fill your plate with plenty of healthy fats, such as coconut oil, avocados, olive oil, ghee and grass-fed butter as well as moderate amounts of protein foods like grass-fed meat, free-range poultry, fatty fish and eggs. Non-starchy vegetables, fresh herbs, nuts, seeds and healthy beverages like water, bone broth and green tea can all be enjoyed as well.


Low carb diets are designed to force your body to burn stored fat as its primary source of fuel. With a typical diet, carbohydrates are burned first, followed by protein, and then fat as the final source of fuel. However, because most people consume far more carbohydrates than are necessary, the excess calories are stored as fat and weight loss is difficult to achieve.
None of the coffee additives caused a significant drop in our blood ketone levels. At 120 minutes, my, (Becky’s), ketone readings increased after drinking black coffee, coffee with cream, coffee with MCT oil, and coffee with butter. At 120 minutes, Keith’s ketone readings dropped by 0.1 mmol/L after drinking only black coffee. His ketone readings rose slightly after consuming coffee with cream, MCT oil, and butter.
Eat one large meal per day, cutting out all other meals and snacks. For those who aren’t interested in checking clocks and calendars, this is probably the easiest option. This is also a good choice for busy individuals who have a lot going on during the day. Just skip breakfast and lunch and have a large dinner that will carry you over through until bedtime.
That window can be shrunk or expanded depending on your needs and preferences but typically, it’s somewhere between 4-7 hours of feeding during the day. Intermittent fasting is a great practice for weight loss, appetite control, digestion, and health on its own. When it’s combined with the keto diet and its benefits, the results can be even better.
Second, fasting seems foreign to many of us simply because nobody talks about it that much. The reason for this is that nobody stands to make much money by telling you to not eat their products, not take their supplements, or not buy their goods. In other words, fasting isn't a very marketable topic and so you're not exposed to advertising and marketing on it very often. The result is that it seems somewhat extreme or strange, even though its really not.
I would like to know what led you to the conclusion to recommend eating in the morning and fasting in the evening instead of the other way around. You do not link any studies here that show TRF in the morning is better than TRF in the evening. You do state “Nighttime eating is well associated with a higher risk of obesity, as well as diabetes.” but I would hazard a guess that alot people that snack into the evening have many other factors at play that could effect their risk of obesity and diabetes and are possibly not fasting at all. I have been doing TRF from 12-8pm every day for almost a year and have seen vast improvements in my health, not least of which is a loss of 70 lbs, so it seems odd to read items 3 and 4 on your 4 ways to use this information for better health. If you have evidence that supports the idea that TRF in the evening is bad then I would like to see it and perhaps change my dieting habbits.
Does adding cream to your coffee make you hungrier throughout the rest of your fast? If yes, then you know you have spiked an insulin response and cream is a no-go for you! Hunger and cravings initially are common, but after a few days of routine fasting, if these symptoms continue, it is an indication that something is triggering an insulin response in you, causing these cravings. Is it something you’re adding to your coffee?
Keep these studies in mind as your body tries to play tricks on you during your first day of fasting.  Even after three days of fasting, health complications are highly unlikely. However, it is important to know about the possible issues that can be caused by fasting. If you choose to incorporate fasting into your daily diet, you typically want to eat every day as well. Occasionally going on a longer period of fasting.
It doesn't matter when you start your 8–hour eating period. You can start at 8am and stop at 4pm. Or you start at 2pm and stop at 10pm. Do whatever works for you. I tend to find that eating around 1pm and 8pm works well because those times allow me to eat lunch and dinner with friends and family. Breakfast is typically a meal that I eat on my own, so skipping it isn't a big deal.
While it’s not technically fasting, some doctors have reported intermittent fasting benefits by allowing such easy-to-digest food as whole fruit during the fasting window. Modifications like these can still give your digestive and metabolic system a needed rest. For example, “Fit for Life” was a popular weight loss book that suggested eating only fruit after supper and before lunch.
As a functional medicine practitioner, I see a wide range of health problems that all stem from chronic inflammation. And while acute inflammation is a natural and healthy response to help fight off pathogenic bacteria and infections, long-term chronic inflammation that doesn’t subside when the threat is gone can contribute to everything from autoimmune conditions to cancer.
Most people make an IF schedule that requires them to fast for 12 to 16 hours a day. During the rest of the time, they eat normal meals and snacks. Sticking to this eating window isn’t as hard at it sounds because most people sleep for about eight of their fasting hours. In addition you’re encouraged to enjoy zero-calorie drinks, like water, tea, and coffee.
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Perhaps most importantly, intermittent fasting is one of the simplest strategies we have for taking bad weight off while keeping good weight on because it requires very little behavior change. This is a very good thing because it means intermittent fasting falls into the category of “simple enough that you'll actually do it, but meaningful enough that it will actually make a difference.”

Intermittent fasting (specifically the 5:2 diet) became popular in the UK in 2012[14][15][16] after the BBC2 television Horizon documentary Eat, Fast and Live Longer.[17] Via sales of best-selling books, it became widely practiced.[18][19] In the United States, intermittent fasting has become a trend among Silicon Valley companies.[20] According to NHS Choices as of 2012, people considering the 5:2 diet should first consult a physician, as fasting can sometimes be unsafe.[18][21] A news item in the Canadian Medical Association Journal expressed concern that promotional material for the diet showed people eating high-calorie food, such as hamburgers and chips, and that this could encourage binge eating since the implication was that "if you fast two days a week, you can devour as much junk as your gullet can swallow during the remaining five days".[22]
After that timespan, your body goes into what is known as the post–absorptive state, which is just a fancy way of saying that your body isn’t processing a meal. The post–absorptive state lasts until 8 to 12 hours after your last meal, which is when you enter the fasted state. It is much easier for you body to burn fat in the fasted state because your insulin levels are low.
On this plan you'll eat clean five days of the week but will not eat anything for two nonconsecutive days of the week. For example, you can fast on Monday and Thursday but eat clean meals on the other days. Food on these five days will look just like the rest of the fasting plans—healthy fats, clean meat sources, vegetables, and some fruit. Keep in mind that this plan is not for beginners, and you should always talk to your doctor before starting any fasting regimen, especially if you are on medication or have a medical condition.

Those studies above, in working with small sample sizes, and different types of fasting than recommended here, would lead me to believe that fasting affects men and women differently, and that many of the weight loss benefits associated with intermittent fasting (that affect insulin and glucose responses) work positively for men and negatively for women.
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