Fasting ramps up your stem cell production.[6] Stem cells are like biological playdough — your body turns them into any kind of cell it needs and uses them to replace old or damaged cells, keeping you younger on a cellular level. Stem cells are great for your skin, joints, old injuries, chronic pain, and more. You can try stem cell therapy…or you can just fast.
For example, in the graphic below you would eat dinner on Monday night and then not eat again until Tuesday evening. On Wednesday, however, you would eat all day and then start the 24–hour fasting cycle again after dinner on Wednesday evening. This allows you to get long fast periods on a consistent basis while also eating at least one meal every day of the week.
Zero-calorie beverages are okay.  I drink green tea in the morning for my caffeine kick while writing. If you want to drink water, black coffee, or tea during your fasted period, that’s okay.  Remember, don’t overthink it – keep things simple! Dr. Rhonda Patrick over at FoundMyFitness believes that a fast should stop at the first consumption of anything other than water, so experiment yourself and see how your body responds.

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The thing is that if you want to slim down and get rid of excess pounds, then the fasted state is really the best way to do it. If you keep taking food into your body, insulin levels will remain high, and you will keep burning glucose for fuel instead of burning fat. Of course, to remain in the fasted state, you need to not be in the fed state, and that can be a problem. Starving yourself all of the time isn’t enjoyable, and it’s not healthy. To be blunt about it, your body needs nutrients, it just doesn’t need them all day, every day.
Crescendo fasting only requires you to fast a few days a week instead of every day. My experience is that women get a lot more benefit from doing it this way without accidentally throwing their hormones into frenzy. This is a more gentle approach that helps the body more easily adapt to fasting. And if women do it right, it can be an amazing way to shave off body fat, improve inflammatory markers and gain energy. (7)
One monk, for example, set out to do a 40 day fast with medical supervision while maintaining his daily activities in the monastery. After 36 days, the medical professionals had to step in due to “profound weakness” and low blood pressure when standing. Although the monk fasted for 15 days longer than Ghandi, the medical professionals were able to stop the fast in time so that he could recover.
In so far as insulin promotes de novo lipogenesis and suppresses lipolysis in adipocytes it DOES help keep the fat inside. But in Hyperinsulinemia / Insulin Resistance with Impaired Glucose Tolerance lipolysis may not be sufficiently reduced and fatty acids and glycerin can be spilled at the same time that Triglycerides are being formed & stored. In the liver the glycerin gets converted to glucose producing hyperglycemia.
Intermittent fasting is probably what you’d think. It’s fasting… intermittently. Or, to be a bit clearer, it’s skipping meals. But while missing a meal will certainly mean fewer calories throughout your day, the magic of intermittent fasting isn’t just in how it reduces food intake, but in how it helps your body make better use of the calories you keep.
For example, in the graphic below you would eat dinner on Monday night and then not eat again until Tuesday evening. On Wednesday, however, you would eat all day and then start the 24–hour fasting cycle again after dinner on Wednesday evening. This allows you to get long fast periods on a consistent basis while also eating at least one meal every day of the week.

So very interesting, I was captivated reading your results—thank you! I would also love to see added to this research the keto effect of just water over those 120 minutes, and then the keto effect of adding collagen powder to your coffee. So appreciative of all that wincing-sticking-your-fingers that you both endured to help give us clarity in what goes on with our ketones and glucose when drinking our coffees with different add-ins. Great read!
Some people believe that IF has worked for them simply because the limited eating window naturally helps them reduce the amount of calories they consume. For instance, instead of eating three meals and two snacks, they might find that they only have time for two meals and one snack. They become more mindful about the kinds of food they consume and tend to stay way from processed carbs, unhealthy fat, and empty calories.

Does adding cream to your coffee make you hungrier throughout the rest of your fast? If yes, then you know you have spiked an insulin response and cream is a no-go for you! Hunger and cravings initially are common, but after a few days of routine fasting, if these symptoms continue, it is an indication that something is triggering an insulin response in you, causing these cravings. Is it something you’re adding to your coffee?
When the female body senses it’s headed towards famine, it will increase the production of the hunger hormones, ghrelin and leptin, which signal the body that you’re hungry and need to eat (2). Additionally, if there’s not enough food for you to survive, your body is going to shut down the system that would allow you to create another human. This is the body’s natural way of protecting a potential pregnancy, even if you’re not actually pregnant or trying to conceive.
While these five methods are the most well-known in terms of integrating periods of fasting into your eating schedule, there are many other similar philosophies based on meal timing. For those who prefer a more fluid, less rigid method, there’s also the concept of eating intuitively. Primal Diet proponent Mark Sisson is a supporter of the Eat WHEN (When Hunger Ensues Naturally) method, where dieters simply eat whenever their bodies ask them to. However, some believe this can also lead to overeating or overconsumption of calories, since our bodies’ hunger-induced choices may be more caloric than otherwise.
There were [no statistical] differences between the low- and high- [meal frequency] groups for adiposity indices, appetite measurements or gut peptides (peptide YY and ghrelin) either before or after the intervention. We conclude that increasing meal frequency does not promote greater body weight loss under the conditions described in the present study.
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